Mild Androgenetic Alopecia
Mild Androgenetic alopecia – AA is also observe in women. This is call “female type androgenetic slopes . This type of hair loss, showing a different pattern among women and progressive loss of hair follicles is more common in women genetically predispose is define as the miniaturization. Miniaturization is define as the transformation of thick hair into thin hair in hair. It is a frequently watch situation. Also, causes higher aesthetic concerns in women compare to men, and this is important because it causes serious stress. It is seen in 12% of women around the age of thirty, and 30-40% between the ages of 60-69. Although it usually progresses at a variable clinical severity and a certain progression rate after adolescence, it can also begin at any age. Finally, the lower the age of onset, the higher the tendency for clinical severity to occur. I will explain mild androgenic alopecia.
Causes of Mild Androgenetic Alopecia in Women
The frequency and severity of mild androgenetic alopecia increase with age in women as well as in men. The role of androgens in hair loss in men is not so clear. Therefore, the concept of female pattern hair loss (CTSD) is thought to be more accurate in defining the disease. CTSD is observed in women with high androgen levels. In these patients, other signs of androgen excess, such as hirsutism and menstrual irregularities are also visible. So , androgen excess is defined as hyperandrogenism. KTDS is actually a picture of hyperandrogenism. However, it may not always be seen with the increase of serum androgen levels.
Most of the female patients with CTSD do not have clinical and biochemical signs of androgen excess. The increase sensitivity of the hair follicles to normal androgen levels in these women may explain this situation. What is more interesting is that people with androgen sensitivity or alpha-reductase deficiency have male pattern hair loss. This proves can occur even in the absence of androgens female-pattern mile androgenetic alopecia.
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In the control group, female hormone-binding globulin (SHBG) levels decreased as shown in several studies. These findings demonstrate that the hair loss with free androgen levels in the blood is a correlation between violence.
In studies on genetic transmission, the causative genes could not determine . Male pattern androgen on the X chromosome, one of the specific gene hair loss eba2r’n receptor gene polymorphism demonstrate in women with early-onset. Also , more mile androgenetic alopecia findings were found in male relatives of women with CTSD than in the normal population.
Clinic of Androgenetic Alopecia in Women
CTSD usually presents with a slow and progressive hair thinning complaint. The affected areas are often the vertex, which is the crown of the hair, the parietal, which is the upper side, and sometimes the anterior and lateral frontoparietal area. In conclusion, the back loss of the anterior hairline show in men is not observed in women.
Three different hair loss patterns can observe in women:
Diffuse examination of the crest, preservation of the frontal hairline (Ludwig type). According to the severity of the spill, Ludwig as 1,2 is grad . The recession of the forehead midline hair and enlargement of the middle of the scalp without diffuse hair loss defined by Olsen . It is call the “pine tree pattern”. Thinning with the bilateral recession in the forehead line. Male type (Hamilton type) has the same distribution pattern as hair loss. Finally, thinning is more noticeable at the top of the hair and on both sides of the forehead. So, women with hair loss in the 1st pattern, Ludwig pattern, may experience 3rd pattern, namely Hamilton type hair loss, after menopause. Female Hair Loss Treatment Reviews
Clinic of Androgenetic Alopecia
BASP classification is an assessment based on patterns of hair loss. The basic hair loss patterns are call Basic types (BA) and show the condition of the anterior hairline. The individual hair loss pattern is call the Specific type (SP) and symbolizes the density of hair on the front and top of the scalp. So, basic types (BA) are four; L; M; C and U. Anterior-lateral hairline-define according to the regression pattern and level of the frontotemporal hairline.
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Specific types (SP) are graded according to the level of hair reduction in the anterior-F and top-V regions of the hair according to the area where the shedding is intense. Then, a result is obtain that is the combination of both types. It was emphasize that it would be a more useful combination to evaluate the true rate and distribution of hair loss.
Diagnosing Androgenetic Alopecia in Women
Basic diagnosis is make clinical examination. Dermoscopy has taken its place among diagnostic methods in hair diseases in recent years and helps to recognize early and make its differential diagnosis. This is call trichoscopy. Can differentiate from chronic telogen effluvium according to trichoscopy criteria. For example, there are more than 4 yellow spots in 4 different areas on the front of the scalp, the hair thickness on the front part of the hair is very low compare to the neck, thinning in the front part of the hair, the presence of more than 10% hair thinner than 30 micron, the increase of single-hair units in follicular units, vellus hair the presence of colour changes around the hair follicles on the scalp.
Androgenetic Alopecia
The important to distinguish it from other causes of hair loss. It should distinguish from acute and chronic telogen effluvium. It is especially important to examine TSH, T4, hemogram, vitamin D and ferritin levels in patients.
Most women do not have clinical and biochemical signs of androgen excess, but patients with signs of hyperandrogenism such as hirsutism, moderate/severe acne, acanthosis nigricans, irregular menstruation, and galactorrhea need hormone tests. First of all, Free and/or total testosterone and levels should be requested.
If there is a high testosterone level, prolactin should also request . So, screening for congenital adrenal hyperplasia with an elevation of testosterone is appropriate.
Androgen-Independent Treatments
Minoxidil
Today, the only approved androgen-independent treatment is minoxidil topical solution. First, thought that by affecting the hair life cycle, it provides the early termination of the telogen period and the prolongation of the anagen phase. It has a potassium channel opening effect and its mechanism of action is still not clear. So, determine that they stimulate the development of new vessels around the hair follicle and by increasing the growth factors of hair (vascular endothelial and hepatocytic growth factors). Finally, it has features that increase the number and weight of the hair. In conclusion, only 2% of the form has approval. 5% solution is effective, but side effects such as local and facial hair growth have been observing. John Travolta Balding